CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotidyltransferases domain 2
Functional Family protein-tyrosine kinase 2-beta isoform X1

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q14289
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60711
LPXN_HUMAN
Homo sapiens
Leupaxin

PDB Structure

PDB 4XEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Vanarotti, M.S., Finkelstein, D.B., Guibao, C.D., Nourse, A., Miller, D.J., Zheng, J.J.
Biochemistry