CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q54727
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q54727
NANB_STRPN
Streptococcus pneumoniae TIGR4
Sialidase B

PDB Structure

PDB 4XE9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
Rogers, G.W., Brear, P., Yang, L., Chen, A.S., Mitchell, J.B.O., Taylor, G.L., Westwood, N.J.
To be published