CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.330 | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Domain Context
CATH Clusters
| Superfamily | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
| Functional Family | Feruloyl CoA ortho-hydroxylase 1 |
Enzyme Information
| 1.14.11.61 |
Feruloyl-CoA 6-hydroxylase.
based on mapping to UniProt Q9LHN8
Trans-feruloyl-CoA + 2-oxoglutarate + O(2) = trans-6-hydroxy-feruloyl-CoA + succinate + CO(2).
-!- Requires iron(II) and ascorbate. -!- The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. -!- The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. -!- Cf. EC 1.14.11.62.
|
UniProtKB Entries (1)
| Q9LHN8 |
F6H1_ARATH
Arabidopsis thaliana
Feruloyl CoA ortho-hydroxylase 1
|
PDB Structure
| PDB | 4XAE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana.
Sci Rep
|
