CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P17612
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17612
KAPCA_HUMAN
Homo sapiens
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 4WB5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into mis-regulation of protein kinase A in human tumors.
Cheung, J., Ginter, C., Cassidy, M., Franklin, M.C., Rudolph, M.J., Robine, N., Darnell, R.B., Hendrickson, W.A.
Proc.Natl.Acad.Sci.USA