CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P23394
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P23394
PRP28_YEAST
Saccharomyces cerevisiae S288C
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

PDB Structure

PDB 4W7S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28.
Jacewicz, A., Schwer, B., Smith, P., Shuman, S.
Nucleic Acids Res.