CATH Domain 4w6eA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt O95271

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt O95271

UniProtKB Entries (1)

O95271

TNKS1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-1

PDB Structure

PDB	4W6E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Johannes, J.W., Almeida, L., Barlaam, B., Boriack-Sjodin, P.A., Casella, R., Croft, R.A., Dishington, A.P., Gingipalli, L., Gu, C., Hawkins, J.L., Holmes, J.L., Howard, T., Huang, J., Ioannidis, S., Kazmirski, S., Lamb, M.L., McGuire, T.M., Moore, J.E., Ogg, D., Patel, A., Pike, K.G., Pontz, T., Robb, G.R., Su, N., Wang, H., Wu, X., Zhang, H.J., Zhang, Y., Zheng, X., Wang, T. Acs Med.Chem.Lett.

Network disruptions