CATH Domain 4v0iB05

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1070	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
	1.10.1070.11	Phosphatidylinositol 3-/4-kinase, catalytic domain

Superfamily	Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

2.7.1.153

Phosphatidylinositol-4,5-bisphosphate 3-kinase.

based on mapping to UniProt O35904

ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

PK3CD_MOUSE

Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB	4V0I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications. Robinson, D., Bertrand, T., Carry, J., Halley, F., Karlsson, A., Mathieu, M., Minoux, H., Perrin, M., Robert, B., Schio, L., Sherman, W. J.Chem.Inf.Model.