CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P36873
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P36873
PP1G_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

PDB Structure

PDB 4UT2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling.
Santos, C.X., Hafstad, A.D., Beretta, M., Zhang, M., Molenaar, C., Kopec, J., Fotinou, D., Murray, T.V., Cobb, A.M., Martin, D., Zeh Silva, M., Anilkumar, N., Schroder, K., Shanahan, C.M., Brewer, A.C., Brandes, R.P., Blanc, E., Parsons, M., Belousov, V., Cammack, R., Hider, R.C., Steiner, R.A., Shah, A.M.
Embo J.