CATH Domain 4unpA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P9WKE1

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_MYCTU

Mycobacterium tuberculosis H37Rv

Thymidylate kinase

PDB Structure

PDB	4UNP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors. Naik, M., Raichurkar, A., Bandodkar, B.S., Varun, B.V., Bhat, S., Kalkhambkar, R., Murugan, K., Menon, R., Bhat, J., Paul, B., Iyer, H., Hussein, S., Tucker, J.A., Vogtherr, M., Embrey, K.J., Mcmiken, H., Prasad, S., Gill, A., Ugarkar, B.G., Venkatraman, J., Read, J., Panda, M. J.Med.Chem.