CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase MRCK beta

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9Y5S2
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9Y5S2
MRCKB_HUMAN
Homo sapiens
Serine/threonine-protein kinase MRCK beta

PDB Structure

PDB 4UAL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Unbekandt, M., Croft, D.R., Crighton, D., Mezna, M., McArthur, D., McConnell, P., Schuttelkopf, A.W., Belshaw, S., Pannifer, A., Sime, M., Bower, J., Drysdale, M., Olson, M.F.
Cell Commun. Signal