CATH Domain 4tu5X00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Dihydrofolate reductase

Enzyme Information

UniProtKB Entries (1)

A0A0M3KKX1_STAAB

Staphylococcus aureus RF122

Dihydrofolate reductase

PDB Structure

PDB	4TU5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus. Keshipeddy, S., Reeve, S.M., Anderson, A.C., Wright, D.L. J.Am.Chem.Soc.