CATH Domain 4s2eB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt O67099

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_AQUAE

Aquifex aeolicus VF5

Thymidylate kinase

PDB Structure

PDB	4S2E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural studies of a hyperthermophilic Thymidylate Kinase enzyme reveal conformational sub-states along the reaction coordinate Biswas, A., Jeyakanthan, J., Sekar, K. Febs J.