CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1970
Functional Family

Enzyme Information

1.1.1.261
sn-glycerol-1-phosphate dehydrogenase.
based on mapping to UniProt Q58122
sn-glycerol 1-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H.
-!- Responsible for the formation of archaea-specific sn-glycerol-1- phosphate, the first step in the biosynthesis of polar lipids in archaea. -!- It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. -!- The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP- unsaturated archaeol. -!- The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine. -!- Activity of the enzyme is stimulated by K(+).

UniProtKB Entries (1)

Q58122
G1PDH_METJA
Methanocaldococcus jannaschii DSM 2661
Glycerol-1-phosphate dehydrogenase [NAD(P)+]

PDB Structure

PDB 4RGQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.
Carbone, V., Schofield, L.R., Zhang, Y., Sang, C., Dey, D., Hannus, I.M., Martin, W.F., Sutherland-Smith, A.J., Ronimus, R.S.
J.Biol.Chem.