CATH Domain 4rboD00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.60	Homeodomain-like

Domain Context

CATH Clusters

Superfamily	Homeodomain-like
Functional Family	Nanog homeobox transcription factor

Enzyme Information

UniProtKB Entries (1)

NANOG_HUMAN

Homo sapiens

Homeobox protein NANOG

PDB Structure

PDB	4RBO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Hayashi, Y., Caboni, L., Das, D., Yumoto, F., Clayton, T., Deller, M.C., Nguyen, P., Farr, C.L., Chiu, H.J., Miller, M.D., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Tomoda, K., Conklin, B.R., Wilson, I.A., Yamanaka, S., Fletterick, R.J. Proc.Natl.Acad.Sci.USA