CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Protein kinase C, theta

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt Q04759
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q04759
KPCT_HUMAN
Homo sapiens
Protein kinase C theta type

PDB Structure

PDB 4RA5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimized Protein Kinase C theta (PKC theta ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis.
George, D.M., Breinlinger, E.C., Argiriadi, M.A., Zhang, Y., Wang, J., Bansal-Pakala, P., Duignan, D.B., Honore, P., Lang, Q., Mittelstadt, S., Rundell, L., Schwartz, A., Sun, J., Edmunds, J.J.
J.Med.Chem.