CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Multidrug resistance protein 1A

Enzyme Information

7.6.2.2
ABC-type xenobiotic transporter.
based on mapping to UniProt P21447
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).
-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- Does not undergo phosphorylation during the transport process. -!- The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. -!- Several distinct enzymes may be present in a single eukaryotic cell. -!- Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1). -!- Formerly EC 3.6.3.44.

UniProtKB Entries (1)

P21447
MDR1A_MOUSE
Mus musculus
Multidrug resistance protein 1A

PDB Structure

PDB 4Q9I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.
Szewczyk, P., Tao, H., McGrath, A.P., Villaluz, M., Rees, S.D., Lee, S.C., Doshi, R., Urbatsch, I.L., Zhang, Q., Chang, G.
Acta Crystallogr.,Sect.D