CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Insulin-degrading enzyme

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P14735
IDE_HUMAN
Homo sapiens
Insulin-degrading enzyme

PDB Structure

PDB 4PES
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of IDE complexed with an inhibitor
Durham, T.B., Toth, J.L., Klimkowski, V.J., Cao, J.X.C., Siesky, A.M., Alexander-Chacko, J., Wu, G.Y., Dixon, J.T., McGee, J.E., Wang, Y., Guo, S., Cavitt, R.N., Schindler, J., Thibodeaux, S.J., Calvert, N.A., Coghlan, M.J., Sindelar, D.K., Christe, M., Kiselyov, V.V., Dodson, M., Sloop, K.W.
To Be Published