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1 keywords

CATH Domain 4or7A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.430 Dihydrofolate Reductase, subunit A
Homologous Superfamily 3.40.430.10 Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

UniProtKB Entries (0)

PDB Structure

PDB 4OR7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity.
Lamb, K.M., Lombardo, M.N., Alverson, J., Priestley, N.D., Wright, D.L., Anderson, A.C.
Antimicrob.Agents Chemother.
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