CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE

Enzyme Information

4.1.2.28
2-dehydro-3-deoxy-D-pentonate aldolase.
based on mapping to UniProt P75682
2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde.
4.1.2.51
2-dehydro-3-deoxy-D-gluconate aldolase.
based on mapping to UniProt P75682
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.

UniProtKB Entries (1)

P75682
YAGE_ECOLI
Escherichia coli K-12
Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE

PDB Structure

PDB 4OE7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of YagE, a KDG aldolase protein, in complex with aldol condensed product of pyruvate and glyoxal
Manoj Kumar, P., Baskar, V., Manicka, S., Krishnaswamy, S.
To be Published