CATH Domain 4o6fA03

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.10	Tetratricopeptide repeat domain

Domain Context

CATH Clusters

Superfamily	Tetratricopeptide repeat domain
Functional Family	N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NRG4
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NRG4 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

ESR1_HUMAN

Homo sapiens

Estrogen receptor

PDB Structure

PDB	4O6F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation. Jiang, Y., Trescott, L., Holcomb, J., Zhang, X., Brunzelle, J., Sirinupong, N., Shi, X., Yang, Z. J.Mol.Biol.