CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family GTP-binding protein Rheb homolog

Enzyme Information

UniProtKB Entries (1)

Q921J2
RHEB_MOUSE
Mus musculus
GTP-binding protein Rheb

PDB Structure

PDB 4O25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Mazhab-Jafari, M.T., Marshall, C.B., Ho, J., Ishiyama, N., Stambolic, V., Ikura, M.
J.Biol.Chem.