CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Possible thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P04818
TYSY_HUMAN
Homo sapiens
Thymidylate synthase

PDB Structure

PDB 4O1U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tethering the dimer-dimer interface of human thymidylate synthase
Ferrari, S., Mangani, S., Pozzi, C., Costi, M.P.
To be Published