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1 keywords

CATH Domain 4o18B02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.4.2.12
Nicotinamide phosphoribosyltransferase.
based on mapping to UniProt P43490
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

UniProtKB Entries (1)

P43490
NAMPT_HUMAN
Homo sapiens
Nicotinamide phosphoribosyltransferase

PDB Structure

PDB 4O18
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.
Wang, W., Elkins, K., Oh, A., Ho, Y.C., Wu, J., Li, H., Xiao, Y., Kwong, M., Coons, M., Brillantes, B., Cheng, E., Crocker, L., Dragovich, P.S., Sampath, D., Zheng, X., Bair, K.W., O'Brien, T., Belmont, L.D.
Plos One
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