CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 4NZQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The linker connecting the two kringles plays a key role in prothrombin activation.
Pozzi, N., Chen, Z., Pelc, L.A., Shropshire, D.B., Di Cera, E.
Proc.Natl.Acad.Sci.USA