CATH Domain 4nxiB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.30	Glutaredoxin
	3.40.30.10	Glutaredoxin

Domain Context

CATH Clusters

Superfamily	Glutaredoxin
Functional Family	Thioredoxin-like reductase Rv2466c

Enzyme Information

UniProtKB Entries (1)

TRLR_MYCTU

Mycobacterium tuberculosis H37Rv

Thioredoxin-like reductase Rv2466c

PDB Structure

PDB	4NXI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. Albesa-Jove, D., Chiarelli, L.R., Makarov, V., Pasca, M.R., Urresti, S., Mori, G., Salina, E., Vocat, A., Comino, N., Mohorko, E., Ryabova, S., Pfieiffer, B., Lopes Ribeiro, A.L., Rodrigo-Unzueta, A., Tersa, M., Zanoni, G., Buroni, S., Altmann, K.H., Hartkoorn, R.C., Glockshuber, R., Cole, S.T., Riccardi, G., Guerin, M.E. Acs Chem.Biol.