CATH Domain 4nreA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.245	Lipoxygenase-1; domain 5
	1.20.245.10	Lipoxygenase-1; Domain 5

Domain Context

CATH Clusters

Superfamily	Lipoxygenase-1; Domain 5
Functional Family	Arachidonate 5-lipoxygenase a

Enzyme Information

1.13.11.33	Arachidonate 15-lipoxygenase. based on mapping to UniProt O15296 Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate. -!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
1.13.11.-	With incorporation of two atoms of oxygen. based on mapping to UniProt O15296

UniProtKB Entries (1)

LX15B_HUMAN

Homo sapiens

Arachidonate 15-lipoxygenase B

PDB Structure

PDB	4NRE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structure of human 15-lipoxygenase-2 with a substrate mimic. Kobe, M.J., Neau, D.B., Mitchell, C.E., Bartlett, S.G., Newcomer, M.E. J.Biol.Chem.