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1 keywords

CATH Domain 4n9cB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

2.4.2.12
Nicotinamide phosphoribosyltransferase.
based on mapping to UniProt P43490
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

UniProtKB Entries (1)

P43490
NAMPT_HUMAN
Homo sapiens
Nicotinamide phosphoribosyltransferase

PDB Structure

PDB 4N9C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y.C., Hua, R., Li, G., Liang, X., Ma, X., O'Brien, T., Oh, A., Skelton, N.J., Wang, C., Wang, W., Wang, Y., Xiao, Y., Yuen, P.W., Zak, M., Zhao, Q., Zheng, X.
Bioorg.Med.Chem.Lett.
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