CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38
Cathepsin K.
based on mapping to UniProt P43235
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235
CATK_HUMAN
Homo sapiens
Cathepsin K

PDB Structure

PDB 4N8W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of collagen fiber degradation by cathepsin K.
Aguda, A.H., Panwar, P., Du, X., Nguyen, N.T., Brayer, G.D., Bromme, D.
Proc.Natl.Acad.Sci.USA