CATH Domain 4n7zA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1120	Arylsulfatase, C-terminal domain
	3.30.1120.130

Domain Context

CATH Clusters

Superfamily	3.30.1120.130
Functional Family	serine/threonine-protein kinase PLK4 isoform X1

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt O00444

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q8TEP8

CE192_HUMAN

Homo sapiens

Centrosomal protein of 192 kDa

PDB Structure

PDB	4N7Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Park, S.Y., Park, J.E., Kim, T.S., Kim, J.H., Kwak, M.J., Ku, B., Tian, L., Murugan, R.N., Ahn, M., Komiya, S., Hojo, H., Kim, N.H., Kim, B.Y., Bang, J.K., Erikson, R.L., Lee, K.W., Kim, S.J., Oh, B.H., Yang, W., Lee, K.S. Nat.Struct.Mol.Biol.