CATH Domain 4m30A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.160	Double Stranded RNA Binding Domain
	3.30.160.20

Domain Context

CATH Clusters

Superfamily	3.30.160.20
Functional Family	Ribonuclease 3

Enzyme Information

3.1.26.3

Ribonuclease III.

based on mapping to UniProt O67082

Endonucleolytic cleavage to 5'-phosphomonoester.

-!- An endoribonuclease that cleaves double-stranded RNA molecules. -!- The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site. -!- Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage. -!- RNase III is involved in both rRNA processing and mRNA processing and decay.

UniProtKB Entries (1)

O67082

RNC_AQUAE

Aquifex aeolicus VF5

Ribonuclease 3

PDB Structure

PDB	4M30
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	RNase III: Genetics and Function; Structure and Mechanism. Court, D.L., Gan, J., Liang, Y.H., Shaw, G.X., Tropea, J.E., Costantino, N., Waugh, D.S., Ji, X. Annu. Rev. Genet.