CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q81EP4
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q81EP4
LDH1_BACCR
Bacillus cereus ATCC 14579
L-lactate dehydrogenase 1

PDB Structure

PDB 4LN1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of L-lactate dehydrogenase from Bacillus cereus ATCC 14579 complexed with calcium, NYSGRC Target 029452
Malashkevich, V.N., Bonanno, J.B., Bhosle, R., Toro, R., Hillerich, B., Gizzi, A., Garforth, S., Kar, A., Chan, M.K., Lafluer, J., Patel, H., Matikainen, B., Chamala, S., Lim, S., Celikgil, A., Villegas, G., Evans, B., Love, J., Fiser, A., Khafizov, K., Seidel, R., Almo, S.C.
To be Published