CATH Domain 4lfdB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.260	Sortase; Chain: A;
	2.40.260.10	Sortase

Domain Context

CATH Clusters

Superfamily	Sortase
Functional Family

Enzyme Information

3.4.22.71

Sortase B.

based on mapping to UniProt A0A0H2XI76

The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a NPXTN motif is cleaved between the Thr and Asn residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.

-!- Belongs to peptidase family C60.

UniProtKB Entries (1)

A0A0H2XI76

A0A0H2XI76_STAA3

Staphylococcus aureus subsp. aureus USA300

Sortase B

PDB Structure

PDB	4LFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Computational Studies of the Staphylococcus aureus Sortase B-Substrate Complex Reveal a Substrate-stabilized Oxyanion Hole. Jacobitz, A.W., Wereszczynski, J., Yi, S.W., Amer, B.R., Huang, G.L., Nguyen, A.V., Sawaya, M.R., Jung, M.E., McCammon, J.A., Clubb, R.T. J.Biol.Chem.

Network disruptions