×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 4labA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.2350 Pseudouridine synthase
Homologous Superfamily 3.30.2350.10 Pseudouridine synthase

Domain Context

CATH Clusters

Superfamily Pseudouridine synthase
Functional Family Pseudouridine synthase

Enzyme Information

5.4.99.22
23S rRNA pseudouridine(2605) synthase.
based on mapping to UniProt P37765
23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).
-!- Pseudouridine synthase RluB converts uridine(2605) of 23S rRNA to pseudouridine.

UniProtKB Entries (1)

P37765
RLUB_ECOLI
Escherichia coli K-12
Ribosomal large subunit pseudouridine synthase B

PDB Structure

PDB 4LAB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Czudnochowski, N., Ashley, G.W., Santi, D.V., Alian, A., Finer-Moore, J., Stroud, R.M.
Nucleic Acids Res.
CATH-Gene3D is a Global Biodata Core Resource Learn more...