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1 keywords

CATH Domain 4l4sH02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00338
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00338
LDHA_HUMAN
Homo sapiens
L-lactate dehydrogenase A chain

PDB Structure

PDB 4L4S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
Dempster, S., Harper, S., Moses, J.E., Dreveny, I.
Acta Crystallogr.,Sect.D
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