CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family PHO system negative regulator

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P17157
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53124
PCL10_YEAST
Saccharomyces cerevisiae S288C
PHO85 cyclin-10

PDB Structure

PDB 4KRC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition.
Zheng, F., Quiocho, F.A.
J.Biol.Chem.