CATH Domain 4kp1A01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.499	Aconitase; domain 3
	3.30.499.10	Aconitase, domain 3

Domain Context

CATH Clusters

Superfamily	Aconitase, domain 3
Functional Family

Enzyme Information

4.2.1.35	(R)-2-methylmalate dehydratase. based on mapping to UniProt P81291 (R)-2-methylmalate = 2-methylmaleate + H(2)O.
4.2.1.31	Maleate hydratase. based on mapping to UniProt P81291 (R)-malate = maleate + H(2)O.
4.2.1.33	3-isopropylmalate dehydratase. based on mapping to UniProt P81291 (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. -!- Forms part of the leucine-biosynthesis pathway. -!- Brings about the interconversion of the two isomers of isopropylmalate.

UniProtKB Entries (1)

LEUC_METJA

Methanocaldococcus jannaschii DSM 2661

Isopropylmalate/citramalate isomerase large subunit

PDB Structure

PDB	4KP1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii Lee, E.H., Lee, K., Hwang, K.Y. Acta Crystallogr.,Sect.D