CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.430 | Dihydrofolate Reductase, subunit A |
|
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
| Superfamily | Dihydrofolate Reductase, subunit A |
| Functional Family | Dihydrofolate reductase |
Enzyme Information
| 1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P9WNX1
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
| P9WNX1 |
DYR_MYCTU
Mycobacterium tuberculosis H37Rv
Dihydrofolate reductase
|
PDB Structure
| PDB | 4KM2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.
Structure
|
