CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family Inhibitor of nuclear factor kappa B kinase subunit beta

Enzyme Information

2.7.11.10
I-kappa-B kinase.
based on mapping to UniProt O14920
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
-!- Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. -!- Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. -!- If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

O14920
IKKB_HUMAN
Homo sapiens
Inhibitor of nuclear factor kappa-B kinase subunit beta

PDB Structure

PDB 4KIK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer.
Liu, S., Misquitta, Y.R., Olland, A., Johnson, M.A., Kelleher, K.S., Kriz, R., Lin, L.L., Stahl, M., Mosyak, L.
J.Biol.Chem.