CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.930 | BirA Bifunctional Protein; domain 2 |
|
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Bira Bifunctional Protein; Domain 2 |
| Functional Family | Bifunctional glutamate/proline--tRNA ligase |
Enzyme Information
| 6.1.1.15 |
Proline--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
|
| 6.1.1.17 |
Glutamate--tRNA ligase.
based on mapping to UniProt P07814
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
|
UniProtKB Entries (1)
| P07814 |
SYEP_HUMAN
Homo sapiens
Bifunctional glutamate/proline--tRNA ligase
|
PDB Structure
| PDB | 4K87 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Acta Crystallogr.,Sect.D
|
