CATH Domain 4jbvA02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Calmodulin-domain protein kinase 1

Enzyme Information

UniProtKB Entries (1)

Q9BJF5_TOXGO

Toxoplasma gondii

Calmodulin-domain protein kinase 1

PDB Structure

PDB	4JBV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Vidadala, R.S., Ojo, K.K., Johnson, S.M., Zhang, Z., Leonard, S.E., Mitra, A., Choi, R., Reid, M.C., Keyloun, K.R., Fox, A.M., Kennedy, M., Silver-Brace, T., Hume, J.C., Kappe, S., Verlinde, C.L., Fan, E., Merritt, E.A., Van Voorhis, W.C., Maly, D.J. Eur.J.Med.Chem.