CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P30405
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P30405
PPIF_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

PDB Structure

PDB 4J5A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rationnal Design of small-molecule inhibitors of human Cyclophilins and HCV replication.
Colliandre, L., Hamed-Belkacem, H., Gelin, M., Bessin, Y., Douguet, D., Bourguet, W., Pawlotsky, J.M., Guichou, J.F.
to be published