CATH Domain 4j52A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	4J52
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Nie, Z., Feher, V., Natala, S., McBride, C., Kiryanov, A., Jones, B., Lam, B., Liu, Y., Kaldor, S., Stafford, J., Hikami, K., Uchiyama, N., Kawamoto, T., Hikichi, Y., Matsumoto, S., Amano, N., Zhang, L., Hosfield, D., Skene, R., Zou, H., Cao, X., Ichikawa, T. Bioorg.Med.Chem.Lett.