CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 4J52
External Links
Primary Citation
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Nie, Z., Feher, V., Natala, S., McBride, C., Kiryanov, A., Jones, B., Lam, B., Liu, Y., Kaldor, S., Stafford, J., Hikami, K., Uchiyama, N., Kawamoto, T., Hikichi, Y., Matsumoto, S., Amano, N., Zhang, L., Hosfield, D., Skene, R., Zou, H., Cao, X., Ichikawa, T.