CATH Domain 4i2yA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.155	Green Fluorescent Protein
	2.40.155.10	Green fluorescent protein

Domain Context

CATH Clusters

Superfamily	Green fluorescent protein
Functional Family

Enzyme Information

2.7.11.18

[Myosin light-chain] kinase.

based on mapping to UniProt P11799

ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.

-!- Requires calmodulin for activity. -!- The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly. -!- Formerly EC 2.7.1.117.

UniProtKB Entries (3)

Q9U6Y8	RFP_DISSP Discosoma sp. Red fluorescent protein drFP583
P11799	MYLK_CHICK Gallus gallus Myosin light chain kinase, smooth muscle
P0DP30	CALM2_RAT Rattus norvegicus Calmodulin-2

PDB Structure

PDB	4I2Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics. Akerboom, J., Carreras Calderon, N., Tian, L., Wabnig, S., Prigge, M., Tolo, J., Gordus, A., Orger, M.B., Severi, K.E., Macklin, J.J., Patel, R., Pulver, S.R., Wardill, T.J., Fischer, E., Schuler, C., Chen, T.W., Sarkisyan, K.S., Marvin, J.S., Bargmann, C.I., Kim, D.S., Kugler, S., Lagnado, L., Hegemann, P., Gottschalk, A., Schreiter, E.R., Looger, L.L. Front Mol Neurosci