CATH Classification

Domain Context

CATH Clusters

Superfamily Receptor L-domain
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04626
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04626
ERBB2_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-2

PDB Structure

PDB 4HRM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
Jost, C., Schilling, J., Tamaskovic, R., Schwill, M., Honegger, A., Plueckthun, A.
Structure