CATH Domain 4gh6B00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase 9A

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76083

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

PDE9A_HUMAN

Homo sapiens

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB	4GH6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design. Meng, F., Hou, J., Shao, Y.X., Wu, P.Y., Huang, M., Zhu, X., Cai, Y., Li, Z., Xu, J., Liu, P., Luo, H.B., Wan, Y., Ke, H. J.Med.Chem.