CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information
Receptor protein-tyrosine kinase.
based on mapping to UniProt P11362
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Fibroblast growth factor receptor 1

PDB Structure

PDB 4F64
External Links
Primary Citation
Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase.
Norman, R.A., Schott, A.K., Andrews, D.M., Breed, J., Foote, K.M., Garner, A.P., Ogg, D., Orme, J.P., Pink, J.H., Roberts, K., Rudge, D.A., Thomas, A.P., Leach, A.G.