CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1240 | Phosphoglycerate mutase-like |
Domain Context
CATH Clusters
| Superfamily | Phosphoglycerate mutase-like |
| Functional Family | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase |
Enzyme Information
| 5.4.2.11 |
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
based on mapping to UniProt O51602
2-phospho-D-glycerate = 3-phospho-D-glycerate.
-!- The enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, some fungi, yeast and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor. -!- The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His(10) in man and Escherichia coli, His(8) in Saccharomyces cerevisiae). -!- This phosphate can be transferred to the free OH of 2-phospho-D- glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine. -!- Cf. EC 5.4.2.12. -!- The enzyme has no requirement for metal ions. -!- This enzyme also catalyze, slowly, the reactions of EC 5.4.2.4. -!- Formerly EC 2.7.5.3 and EC 5.4.2.1.
|
UniProtKB Entries (1)
| O51602 |
GPMA_BORBU
Borreliella burgdorferi B31
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
|
PDB Structure
| PDB | 4EMB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a phosphoglycerate mutase gpmA from Borrelia burgdorferi B31
To be Published
|
