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1 keywords

CATH Domain 4ec3A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.43 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
Homologous Superfamily 3.30.43.10 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Domain Context

CATH Clusters

Superfamily Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family

Enzyme Information

1.21.3.3
Reticuline oxidase.
based on mapping to UniProt P30986
(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).
-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.

UniProtKB Entries (1)

P30986
RETO_ESCCA
Eschscholzia californica
Reticuline oxidase

PDB Structure

PDB 4EC3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme.
Wallner, S., Winkler, A., Riedl, S., Dully, C., Horvath, S., Gruber, K., Macheroux, P.
Biochemistry
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