CATH Domain 4dp3A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

UniProtKB Entries (1)

D9N170_PLAFA

Plasmodium falciparum

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	4DP3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S.A., McLennan, D.N., White, K.L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W.N., Matthews, D. Proc.Natl.Acad.Sci.USA