CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00523
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523
SRC_CHICK
Gallus gallus
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 4DGG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active site profiling reveals coupling between domains in SRC-family kinases.
Krishnamurty, R., Brigham, J.L., Leonard, S.E., Ranjitkar, P., Larson, E.T., Dale, E.J., Merritt, E.A., Maly, D.J.
Nat.Chem.Biol.